Rank #5Pilot RCTOA (PLOS/PMC)
MISCI trial: multimodal intervention vs health awareness
PLOS ONE • 2022
Chatterjee P, et al.
Quick takeaway
This pilot randomized trial tested a multimodal package against health-awareness control in older adults with subjective cognitive impairment. The results support early-stage, multidomain prevention before more severe decline sets in.
Why this matters
High-ranked because it combines diet, exercise, and cognitive training in an India-specific randomized design with open full text.
Key caution
Pilot scale means the study is promising but not definitive for long-term clinical outcomes.