Evidence summary

MISCI trial: multimodal intervention vs health awareness

PLOS ONE · 2022Chatterjee P, et al.
Open source

Quick takeaway

This pilot randomized trial tested a multimodal package against health-awareness control in older adults with subjective cognitive impairment. The results support early-stage, multidomain prevention before more severe decline sets in.

Why this matters

High-ranked because it combines diet, exercise, and cognitive training in an India-specific randomized design with open full text.

Key caution

Pilot scale means the study is promising but not definitive for long-term clinical outcomes.

MISCI trial: multimodal intervention vs health awareness